Select Publications
current/past lab members highlighted in bold | *denotes co-first authorship I #denotes co-corresponding authorship
2023
Patel S, Sparman NZR, Arneson D, Alvarsson A, Santos LC, Duesman SJ, Centonze A, Hathaway E, Ahn IS, Diamante G, Cely I, Cho CH, Talari NK, Rajbhandari AK, Goedeke L, Wang P, Butte AJ, Blanpain C, Chella Krishnan K, Lusis AJ, Stanley SA, Yang X, Rajbhandari P. Mammary duct luminal epithelium controls adipocyte thermogenic programme. Nature. 2023 Aug;620(7972):192-199. doi: 10.1038/s41586-023-06361-5. Epub 2023 Jul 26. PMID: 37495690.
Hubbard BT, LaMoia TE, Goedeke L, Gaspar RC, Galsgaard KD, Kahn M, Mason GF, Shulman GI. Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo. Cell Metab. 2023 Jan 3;35(1):212-226.e4. doi: 10.1016/j.cmet.2022.11.011. Epub 2022 Dec 13. PMID: 36516861; PMCID: PMC9887731.
2022
Goedeke L, Murt KN, Di Francesco A, Camporez JP, Nasiri AR, Wang Y, Zhang XM, Cline GW, de Cabo R, Shulman GI. Sex- and strain-specific effects of mitochondrial uncoupling on age-related metabolic diseases in high-fat diet-fed mice. Aging Cell. 2022 Feb;21(2):e13539. doi: 10.1111/acel.13539. Epub 2022 Jan 28. PMID: 35088525; PMCID: PMC8844126.
2021
Goedeke L, Canfrán-Duque A, Rotllan N, Chaube B, Thompson BM, Lee RG, Cline GW, McDonald JG, Shulman GI, Lasunción MA, Suárez Y, Fernández-Hernando C. MMAB promotes negative feedback control of cholesterol homeostasis. Nat Commun. 2021 Nov 8;12(1):6448. doi: 10.1038/s41467-021-26787-7. PMID: 34750386; PMCID: PMC8575900.
Goedeke L#, Shulman GI#. Therapeutic potential of mitochondrial uncouplers for the treatment of metabolic associated fatty liver disease and NASH. Mol Metab. 2021 Apr;46:101178. doi: 10.1016/j.molmet.2021.101178. Epub 2021 Feb 3. PMID: 33545391; PMCID: PMC8085597.
2019
Goedeke L, Peng L, Montalvo-Romeral V, Butrico GM, Dufour S, Zhang XM, Perry RJ, Cline GW, Kievit P, Chng K, Petersen KF, Shulman GI. Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates. Sci Transl Med. 2019 Oct 2;11(512):eaay0284. doi: 10.1126/scitranslmed.aay0284. PMID: 31578240; PMCID: PMC6996238.
Goedeke L, Perry RJ, Shulman GI. Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes. Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:65-87. doi: 10.1146/annurev-pharmtox-010716-104727. PMID: 30625285; PMCID: PMC7198260.
2018
Goedeke L, Bates J, Vatner DF, Perry RJ, Wang T, Ramirez R, Li L, Ellis MW, Zhang D, Wong KE, Beysen C, Cline GW, Ray AS, Shulman GI. Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents. Hepatology. 2018 Dec;68(6):2197-2211. doi: 10.1002/hep.30097. PMID: 29790582; PMCID: PMC6251774.
2016
Goedeke L, Wagschal A, Fernández-Hernando C, Näär AM. miRNA regulation of LDL-cholesterol metabolism. Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2047-2052. doi: 10.1016/j.bbalip.2016.03.007. Epub 2016 Mar 9. PMID: 26968099; PMCID: PMC5375104.
2015
Goedeke L, Rotllan N, Ramírez CM, Aranda JF, Canfrán-Duque A, Araldi E, Fernández-Hernando A, Langhi C, de Cabo R, Baldán Á, Suárez Y, Fernández-Hernando C. miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice. Atherosclerosis. 2015 Dec;243(2):499-509. doi: 10.1016/j.atherosclerosis.2015.09.033. PMID: 26520906; PMCID: PMC4975922.
Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, Vrbanac V, Lu YC, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fernández-Hernando C, Kaplan LM, Bernards A, Gerszten RE, Näär AM. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nat Med. 2015 Nov;21(11):1290-7. doi: 10.1038/nm.3980. Epub 2015 Oct 26. PMID: 26501192; PMCID: PMC4993048.
Goedeke L, Rotllan N, Canfrán-Duque A, Aranda JF, Ramírez CM, Araldi E, Lin CS, Anderson NN, Wagschal A, de Cabo R, Horton JD, Lasunción MA, Näär AM, Suárez Y, Fernández-Hernando C. MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nat Med. 2015 Nov;21(11):1280-9. doi: 10.1038/nm.3949. Epub 2015 Oct 5. PMID: 26437365; PMCID: PMC4711995.
2014
Goedeke L, Fernández-Hernando C. MicroRNAs: a connection between cholesterol metabolism and neurodegeneration. Neurobiol Dis. 2014 Dec;72 Pt A:48-53. doi: 10.1016/j.nbd.2014.05.034. Epub 2014 Jun 5. PMID: 24907491; PMCID: PMC4252369.
Goedeke L, Salerno A, Ramírez CM, Guo L, Allen RM, Yin X, Langley SR, Esau C, Wanschel A, Fisher EA, Suárez Y, Baldán A, Mayr M, Fernández-Hernando C. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol Med. 2014 Sep;6(9):1133-41. doi: 10.15252/emmm.201404046. PMID: 25038053; PMCID: PMC4197861.
Goedeke L, Aranda JF, Fernández-Hernando C. microRNA regulation of lipoprotein metabolism. Curr Opin Lipidol. 2014 Aug;25(4):282-8. doi: 10.1097/MOL.0000000000000094. PMID: 24978143; PMCID: PMC5315358.
2013
Goedeke L, Vales-Lara FM, Fenstermaker M, Cirera-Salinas D, Chamorro-Jorganes A, Ramírez CM, Mattison JA, de Cabo R, Suárez Y, Fernández-Hernando C. A regulatory role for microRNA 33* in controlling lipid metabolism gene expression. Mol Cell Biol. 2013 Jun;33(11):2339-52. doi: 10.1128/MCB.01714-12. Epub 2013 Apr 1. PMID: 23547260; PMCID: PMC3648071.
Ramírez CM, Goedeke L, Rotllan N, Yoon JH, Cirera-Salinas D, Mattison JA, Suárez Y, de Cabo R, Gorospe M, Fernández-Hernando C. MicroRNA 33 regulates glucose metabolism. Mol Cell Biol. 2013 Aug;33(15):2891-902. doi: 10.1128/MCB.00016-13. Epub 2013 May 28. PMID: 23716591; PMCID: PMC3719675.
2012
Goedeke L, Fernández-Hernando C. Regulation of cholesterol homeostasis. Cell Mol Life Sci. 2012 Mar;69(6):915-30. doi: 10.1007/s00018-011-0857-5. Epub 2011 Oct 19. PMID: 22009455.
2011
Dávalos A*, Goedeke L*, Smibert P, Ramírez CM, Warrier NP, Andreo U, Cirera-Salinas D, Rayner K, Suresh U, Pastor-Pareja JC, Esplugues E, Fisher EA, Penalva LO, Moore KJ, Suárez Y, Lai EC, Fernández-Hernando C. miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9232-7. doi: 10.1073/pnas.1102281108. Epub 2011 May 16. PMID: 21576456; PMCID: PMC3107310.
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